Protein Details: Calcium release-activated calcium channel protein 1

Protein ID

ICDB_Pro_1752

Protein Name

Calcium release-activated calcium channel protein 1

Gene Name

orai1 tmem142a

Organism

Xenopus laevis (African clawed frog)

Length

258 amino acids

AlphaFoldDB

AF-Q5EAU0-F1-model_v4.pdb

Function

Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores.

Sequence

MYPECGVETKSRPCSKQLQEEVSYPEWISRSYVELMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLEPNHAYPPGLLIAFSACTTVLVAVHLFALMVSTCILPNIEAVSNVHNLNSVKESPHERMHHHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPVNSPKISSNETSAVSSGQAAAITSTAIMVPFGLVFIVFAVHFYRSLVSHKTDRQFQELNELAELAQLQDQLDHRGDPVQSPVHYA

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

RefSeq

NP_001089486.1